Objective To develop a treatment compliance scale for children with autism spectrum disorder（ASD）（parental version）,and to evaluate the reliability and validity. Methods Based on the conceptual model of drug self-management and evaluation theory of rehabilitation prescription compliance,we formed a pretest scale by literature review,interview and expert consultation. To analyze items of the scale and test the reliability and validity,we processed a survey among 290 parents of children with ASD in outpatient department of 2 tertiary hospitals and 3 children’s rehabilitation centres in Guangzhou from August 2020 to January 2021. Participants were selected by convenience sampling. Results The treatment compliance scale for children with ASD includes 2 subscales. Subscale 1 is medication compliance scale（optional）,with 4 items in total. Subscale 2 is a rehabilitation treatment compliance scale,consisting of 18 items in 3 dimensions. The cumulative variance contribution rate of subscale 1 was 72.66%. Regarding Subscale 2,there are 3 common factors being extracted,with cumulative variance contribution rate of 61.71%. Subscale 1 and subscale 2 had the same content validity index（CVI） of 0.930,and CVI of each item ranged from 0.800 to 1.000. The Cronbach’s α coefficients of subscales 1 and subscale 2 were 0.870 and 0.902,and the Cronbach’s α coefficients of each dimension were 0.760~0.909. Conclusion The treatment compliance scale for children with ASD（parental version） has good reliability and validity,and it can be used to evaluate the treatment compliance of children with ASD. This scale provides scientific support for further optimization treatment and nursing of ASD children to improve the prognosis of ASD children and reduce the burden of disease.